Portal de Periódicos da CAPES

Chemoprevention with green propolis green propolis extracted in L-lysine versus carcinogenesis promotion with L-lysine in N-Butyl-N-[4-hydroxybutyl] nitrosamine (BBN) induced rat bladder cancer

2012; Sociedade Brasileira Para o Desenvolvimento da Pesquisa em Cirurgia; Volume: 27; Issue: 2 Linguagem: Inglês

10.1590/s0102-86502012000200015

1678-2674

Conceição Aparecida Dornelas, Francisco Vagnaldo Fechine-Jamacaru, Irineu Lima Albuquerque, Hemerson Iury Ferreira Magalhães, Adjair Jairo Silva de Souza, Leonardo Alcântara Alves, Paulo Roberto Carvalho de Almeida, Telma L. G. Lemos, José Daniel Vieira de Castro, Maria Elisabete Amaral de Moraes, Manoel Odorico de Moraes,

Insect and Pesticide Research

PURPOSE: To determine the effects of green propolis extracted in L-lysine (WSDP) and of L- lysine for 40 weeks on induced rat bladder carcinogenesis. METHODS: The animals (groups I, II, III, IV, V and VI) received BBN during 14 weeks. Group I was treated with propolis 30 days prior received BBN, and then these animals were treated daily with propolis; Groups II and III was treated with subcutaneous and oral propolis (respectively) concurrently with BBN. The animals of Group IV were treated L-lysine; Group V received water subcutaneous; and Group VI received only to BBN. Among the animals not submitted to carcinogenesis induction, Group VII received propolis, Group VIII received L-lysine and Group IX received water. RESULTS: The carcinoma incidence in Group I was lower than that of control (Group VI). The carcinoma multiplicity in Group IV was greater than in Group VI. All animals treated with L-lysine developed carcinomas, and they were also more invasive in Group IV than in controls. On the other hand, Group VIII showed no bladder lesions. CONCLUSION: The WSDP is chemopreventive against rat bladder carcinogenesis, if administered 30 days prior to BBN , and that L-lysine causes promotion of bladder carcinogenesis.