Metabolism and distribution of cannabinoids in rats after different methods of administration
1973; Elsevier BV; Volume: 22; Issue: 13 Linguagem: Inglês
10.1016/0006-2952(73)90028-2
ISSN1873-2968
Autores Tópico(s)Neuroscience and Neuropharmacology Research
ResumoLungs of rats given 14C-Δ9-tetrahydrocannabinol (Δ9-THC) by smoke inhalation showed a retention and metabolism of the cannabinoid, with further retention and metabolism by the liver. Only the liver showed retention and metabolism when 14C-Δ9-THC was given by i.v. injection. The brain showed a greater penetration or retention of unmetabolized cannabinoid after smoke inhalation than after i.v. injection. 11-Hydroxy-Δ9-THC was observed soon after smoke inhalation of 14C-Δ9-THC in all of the organs and tissues except brain, and concentrations of a dihydroxy metabolite increased with time. A still unidentified metabolite was retained in the liver and spleen 15 days after an i.v. or chronic i.p. injection of 14C-Δ8-THC or 14C-Δ9-THC.
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