Enfurvitide prevents vertical transmission of multidrug-resistant HIV-1 in pregnancy but does not cross the placenta
2006; Lippincott Williams & Wilkins; Volume: 20; Issue: 2 Linguagem: Inglês
10.1097/01.aids.0000200535.02232.1b
ISSN1473-5571
AutoresPaul Brennan-Benson, Mark Pakianathan, Philip Rice, Stefano Bonora, Rana Chakraborty, Mike Sharland, Phillip Hay,
Tópico(s)HIV-related health complications and treatments
ResumoThe use of previously successful antiretroviral regimens in mother-to-child transmission (MTCT) prevention will be increasingly challenged by the rising prevalence of multidrug-resistant (MDR) HIV. We used enfurvitide together with an optimized antiretroviral backbone to prevent the MTCT prevention of MDR HIV in two pregnant women. The measurement of maternal and foetal peripheral blood levels of enfurvitide showed no evidence of transplacental transfer.
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