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A Further Study of the Carcinogenic Properties of Ortho Hydroxy-Amines and Related Compounds by Bladder Implantation in the Mouse

1956; Springer Nature; Volume: 10; Issue: 3 Linguagem: Inglês

10.1038/bjc.1956.63

1532-1827

Georgiana M. Bonser, Lisa Bradshaw, David B. Clayson, J. W. Jull,

Sulfur Compounds in Biology

Bonser, Clayson, Jull and Pyrah examined the carcinogenic action of 2-naphthylamine (I) and the hydrochloride of one of its metabolites, namely, 2-amino-1-naphthol (II), by means of the implantation of paraffin wax pellets containing the chemicals into the lumen of the mouse bladder.On the basis of experiments on forty-two mice they concluded that whereas the parent amine, 2-naphthylamine, was not active under these conditions the metabolite, 2-amino- 1-naphthol was carcinogenic.The carcinogenicity of 2-amino-l-naphthol and the absence of such activity with 2-naphthylamine led Clayson (1953) to suggest that aromatic amines and