Portal de Periódicos da CAPES

Artigo Produção Nacional Revisado por pares

BIBTEX RIS

Polysaccharides isolated from Digenea simplex inhibit inflammatory and nociceptive responses

2014; Elsevier BV; Volume: 108; Linguagem: Inglês

10.1016/j.carbpol.2014.01.105

1879-1344

Juliana Gomes Pereira, Jacilane Ximenes Mesquita, Karoline S. Aragão, Álvaro Xavier Franco, Marcellus Henrique Loiola Ponte de Souza, Tarcísio Vieira de Brito, Jordana Maia Dias, Renan O. Silva, Jand Venes Rolim Medeiros, Jefferson Soares de Oliveira, Clara M.W.S. Abreu, Regina C.M. de Paula, André Luiz dos Reis Barbosa, Ana Lúcia Ponte Freitas,

Echinoderm biology and ecology

Polysaccharides (PLS) have notably diverse pharmacological properties. In the present study, we investigated the previously unexplored anti-inflammatory and antinociceptive activities of the PLS fraction isolated from the marine red alga Digenea simplex. We found that the PLS fraction reduced carrageenan-induced edema in a dose-dependent manner, and inhibited inflammation induced by dextran, histamine, serotonin, and bradykinin. The fraction also inhibited neutrophil migration into both mouse paw and peritoneal cavity. This effect was accompanied by decreases in IL1-β and TNF-α levels in the peritoneal fluid. Pre-treatment of mice with PLS (60 mg/kg) significantly reduced acetic acid-induced abdominal writhing. This same dose of PLS also reduced total licking time in both phases of a formalin test, and increased latency in a hot plate test. Therefore, we conclude that PLS extracted from D. simplex possess anti-inflammatory and antinociceptive activities and can be useful as therapeutic agents against inflammatory diseases.