Portal de Periódicos da CAPES

Artigo Produção Nacional Revisado por pares

BIBTEX RIS

Preparation and Characterization of Polymeric Nanocapsules Produced by in Situ Polymerization From Nanoemulsions Produced by Direct Emulsification

2013; Taylor & Francis; Volume: 34; Issue: 2 Linguagem: Inglês

10.1080/01932691.2012.658321

1532-2351

Patrícia L. Goto, José Mário Carneiro Vilela, Margareth Spangler Andrade, Orlando David Henrique dos Santos,

Electrohydrodynamics and Fluid Dynamics

AbstractPolymeric nanoparticles constitute an important drug delivery system with controlled release profile. This article describes a new way to produce polymeric nanocapsules using a vegetable oil nanoemulsion as template. The process occurs in two steps: First, a nanoemulsion was obtained with a low-energy method based on phase inversion emulsification, using 2-ethylhexyl acrylate as lipophilic monomer. The in situ polymerization of the nanoemulsion droplets is induced by the addition of polymerization catalyzers. The mean size of the polymeric nanoparticles was evaluated by photon correlation spectroscopy and atomic force microscopy. Both techniques showed the formation of polymeric nanocapsules with a mean particle size less than 300 nm.Keywords: In situ polymerizationphase inversion emulsificationpolymeric nanoparticlesvegetable oil AcknowledgementsThis work was financially supported by Fundação de Amparo a Pesquisa do Estado de Minas Gerais—FAPEMIG (EDT-161-07; PPM-00537-09, Rede Mineira de Nanobiotecnologia–NanoBiotecMG) and Conselho Nacional de Desenvolvimento Científico e Tecnologico-CNPq (577247/2008-5).