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Synthesis of (-)-Neplanocin A

2005; Georg Thieme Verlag; Volume: 2006; Issue: 01 Linguagem: Inglês

10.1055/s-2005-921662

1861-1958

Leo A. Paquette, Zhen‐Yu Tian, Christopher K. Seekamp, T. Wang,

Synthesis and pharmacology of benzodiazepine derivatives

(-)-Neplanocin A is an antiviral carbocyclic nucleoside isolated from Ampullariella regularis. It is thought to act by inhibition of S-adenosylhomocystine. The synthesis is noteworthy for its use of a zirconocene-mediated ring contraction in the key step.