Portal de Periódicos da CAPES

Regulation of cyclin D1 gene expression

2010; Portland Press; Volume: 38; Issue: 1 Linguagem: Inglês

10.1042/bst0380217

1470-8752

Ini‐Isabée Witzel, Li Fang Koh, Neil D. Perkins,

RNA and protein synthesis mechanisms

Cyclin D1 is a key regulator of cell proliferation and its expression is subject to both transcriptional and post-transcriptional regulation. In different cellular contexts, different pathways assume a dominant role in regulating its expression, whereas their disregulation can contribute to overexpression of cyclin D1 in tumorigenesis. Here, we discuss the ability of the NF-κB (nuclear factor κB)/IKK [IκB (inhibitor of NF-κB) kinase] pathways to regulate cyclin D1 gene transcription and also consider the newly discovered role of the SNARP (SNIP1/SkIP-associated RNA processing) complex as a co-transcriptional regulator of cyclin D1 RNA stability.