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Cue utilization and hippocampal lesions in rats

1978; Springer Nature; Volume: 6; Issue: 3 Linguagem: Inglês

10.3758/bf03326726

0090-5046

Frederick G. Freeman,

Zebrafish Biomedical Research Applications

Hippocampal lesioned and sham-operated control rats were trained on a go, no-go task to assess the importance of multiple relevant cues on learning. When one stimulus (e.g., a light) was presented during the go trials and a second stimulus (e.g., a tone) was presented during the no-go trials, the lesioned animals performed more poorly than the control animals. However, when a light-tone combination was presented during the go (or no-go in a second condition) trials, and their absence signified the no-go trials (or the go trials), the performance of the lesioned and control animals did not differ. The data suggest that the use of multiple cues in an operant go, no-go discrimination task does not necessarily eliminate the learning deficit typically seen on this task by animals with hippocampal lesions. The manner in which these cues are presented is also important.