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Excretion of trans-Δ9-Tetrahydrocannabinol and Its Metabolites in Intact and Bile Duct-Cannulated Rats

1973; Elsevier BV; Volume: 62; Issue: 5 Linguagem: Inglês

10.1002/jps.2600620506

1520-6017

Robert F. Turk, Louis S. Harris, William L. Dewey,

Diet, Metabolism, and Disease

Tritiated Δ9-tetrahydrocannabinol (I) was administered both orally and intravenously to groups of bile duct-cannulated rats and those with their bile duct intact. From 55.8 to 66.9% of the total radioactivity was excreted during the 96-hr. period following administration. The excretion of radioactivity was minimal in each group beyond 48 hr. after drug administration. The major route of excretion following the intravenous administration in bile duct-cannulated rats was by way of bile (59.4%; feces, 2.7%), whereas more radioactivity was excreted in feces (41.5%) than bile (21.5%) when the drug was given orally. The radioactivity excreted in the feces of the orally medicated rats was mainly extractable in petroleum ether. This extract was found to contain I by TLC and GLC analysis. After intravenous administration, the radioactivity in the feces was not extractable in petroleum ether but appeared in ether, methanol, and water extracts. TLC confirmed that the radioactivity in these solvents was associated with metabolites of I. Bile contained mainly metabolites of I, as did the urine. Less than 10% of the radioactivity was excreted in the urine of each group of rats.