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Hydrophobic Gold Nanoparticle Self-Assembly with Phosphatidylcholine Lipid: Membrane-Loaded and Janus Vesicles

2010; American Chemical Society; Volume: 10; Issue: 9 Linguagem: Inglês

10.1021/nl102387n

1530-6992

Michael Rasch, Emma Rossinyol, José L. Hueso, Brian W. Goodfellow, Jordi Arbiol, Brian A. Korgel,

Nanoparticle-Based Drug Delivery

Hybrids of hydrophobic sub-2-nm-diameter dodecanethiol-coated Au nanoparticles and phosphatidylcholine (PC) lipid vesicles made by extrusion were examined by cryogenic transmission electron microscopy (cryoTEM). The nanoparticles loaded the vesicles as a dense monolayer in the hydrophobic core of the lipid bilayer, without disrupting their structure. Nanoparticle−vesicle hybrids could also be made by a dialysis process, mixing preformed vesicles with detergent-stabilized nanoparticles, but this approach led to vesicles only partially loaded with nanoparticles that segregated into hemispherical domains, forming a Janus vesicle−nanoparticle hybrid structure.