Produção Nacional
Revisado por pares
Paroniquia en pacientes infectados por el VIH tratados con indinavir
2001; Elsevier BV; Volume: 201; Issue: 8 Linguagem: Inglês
10.1016/s0014-2565(01)70878-8
ISSN1578-1860
AutoresM J García García, Luís Morano, Francisco Rodríguez, Cristina Álvarez, Antonio Ocampo,
Tópico(s)HIV/AIDS drug development and treatment
ResumoA retrospective study of cases of paronychia associated with anti-retroviral therapy diagnosed in two general hospitals is here reported. Lesions appeared from 3 and 48 months after institution of therapy. At diagnosis, 84.6% of patients were on indinavir therapy. CD4 values ranged from 120 and 1,332 cells/mm3 and viral load was lower than 200 copies/ml in 92.3 of cases. Conservative therapy was applied in 7 patients and surgery in 6. In all patients indinavir therapy was discontinued, and cure was achieved 16 weeks later. The "retinoid" effect of indinavir is discussed as likely pathogenic explanation for this complications. We advocate for topic therapy and change of anti-retroviral therapy, reserving surgery for patients not responding to therapy. Pain and functional limitation caused by this non uncommon complication (1.6% of our patients treated with anti-retroviral agents) makes its knowledge necessary and an active search by clinicians in patients receiving indinavir therapy.
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