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The Reactome pathway Knowledgebase

2015; Oxford University Press; Volume: 44; Issue: D1 Linguagem: Inglês

10.1093/nar/gkv1351

1362-4962

Antonio Fabregat, Konstantinos Sidiropoulos, Phani Garapati, Marc Gillespie, Kerstin Hausmann, Robin Haw, Bijay Jassal, S Jupe, Florian Korninger, Sheldon McKay, Lisa Matthews, Bruce May, M Orlic-Milacic, Karen Rothfels, Veronica Shamovsky, Marissa Webber, Joel Weiser, Mark Williams, Guanming Wu, Lincoln Stein, Henning Hermjakob, Peter D’Eustachio,

Biomedical Text Mining and Ontologies

Reactome (http://www.reactome.org) is a manually curated open-source open-data resource of human pathways and reactions. The current version 46 describes 7088 human proteins (34% of the predicted human proteome), participating in 6744 reactions based on data extracted from 15 107 research publications with PubMed links. The Reactome Web site and analysis tool set have been completely redesigned to increase speed, flexibility and user friendliness. The data model has been extended to support annotation of disease processes due to infectious agents and to mutation.