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Hydroxyethylstarch and renal function in kidney transplant recipients

1997; Elsevier BV; Volume: 349; Issue: 9055 Linguagem: Inglês

10.1016/s0140-6736(05)61796-5

1474-547X

Bernard Coronel, A. Mercatello, Xavier Martín, N Lefrançois,

Renal and Vascular Pathologies

Cittanova and colleagues' report1Cittanova M Leblanc I Legendre C Mouquet C Riou B Coriat P Effect of hydroxyethylstarch in brain-dead kidney donors on renal function in kidney-transplant recipients.Lancet. 1996; 348: 1620-1622Summary Full Text Full Text PDF PubMed Scopus (357) Google Scholar has led us to review our data in 24 recipients of kidney grafts. We found no difference in the kidney-graft function at 1, 3, and 6 months post-transplantation, irrespective of hydroxyethylstarch use in brain-dead organ donors. The frequency of osmotic nephrotic-like lesions was also similar in those who had received hydroxyethylstarch and those who had not, and had no effect on kidney-graft function at these times after transplantation.2Coronel B Mercatello A Colon S Martin X Moskovtchenko J Hydroxyethylstarch and osmotic nephrosislike lesions in kidney transplants.Lancet. 1996; 348: 1595Google Scholar By contrast, Cittanova and colleagues recorded, during the first 10 days post-transplantation, reduced kidney-graft function with higher creatininaemia or more requirements for haemodialysis in recipients in the hydroxyethylstarchgelatin group. In our study, creatininaemia in the first 10 days post-transplantation was lower in the hydroxyethlystarch group. This discrepancy between the two studies could be caused by the sex-ratio in Cittanova's hydroxyethylstarch-gelatin group which had more men than women. We therefore examined the sex ratio in our recipients, and there were 12 men and 12 women. Creatininaemia in the men was higher than in the women in the first 10 days post-transplantation and was equal thereafter (figure).Thus, the differences between the two studies could be attributable to the sex-ratio of the groups of recipients. In the longterm, would the evolution of creatininaemia be similar in men and women, as Legendre and colleagues' results have suggested3Legendre C Thervet E Page B Percheron A Noël L Kreis H Hydroxyethylstarch and osmotic-nephrosislike lesions in kidney transplantation.Lancet. 1993; 342: 248-249Abstract PubMed Scopus (191) Google Scholar? Cittanova and colleagues' report1Cittanova M Leblanc I Legendre C Mouquet C Riou B Coriat P Effect of hydroxyethylstarch in brain-dead kidney donors on renal function in kidney-transplant recipients.Lancet. 1996; 348: 1620-1622Summary Full Text Full Text PDF PubMed Scopus (357) Google Scholar has led us to review our data in 24 recipients of kidney grafts. We found no difference in the kidney-graft function at 1, 3, and 6 months post-transplantation, irrespective of hydroxyethylstarch use in brain-dead organ donors. The frequency of osmotic nephrotic-like lesions was also similar in those who had received hydroxyethylstarch and those who had not, and had no effect on kidney-graft function at these times after transplantation.2Coronel B Mercatello A Colon S Martin X Moskovtchenko J Hydroxyethylstarch and osmotic nephrosislike lesions in kidney transplants.Lancet. 1996; 348: 1595Google Scholar By contrast, Cittanova and colleagues recorded, during the first 10 days post-transplantation, reduced kidney-graft function with higher creatininaemia or more requirements for haemodialysis in recipients in the hydroxyethylstarchgelatin group. In our study, creatininaemia in the first 10 days post-transplantation was lower in the hydroxyethlystarch group. This discrepancy between the two studies could be caused by the sex-ratio in Cittanova's hydroxyethylstarch-gelatin group which had more men than women. We therefore examined the sex ratio in our recipients, and there were 12 men and 12 women. Creatininaemia in the men was higher than in the women in the first 10 days post-transplantation and was equal thereafter (figure). Thus, the differences between the two studies could be attributable to the sex-ratio of the groups of recipients. In the longterm, would the evolution of creatininaemia be similar in men and women, as Legendre and colleagues' results have suggested3Legendre C Thervet E Page B Percheron A Noël L Kreis H Hydroxyethylstarch and osmotic-nephrosislike lesions in kidney transplantation.Lancet. 1993; 342: 248-249Abstract PubMed Scopus (191) Google Scholar? Hydroxyethylstarch and renal function in kidney transplant recipientsAuthor's reply Full-Text PDF