Synthesis and Characterization of Dual Modality (CT/MRI) Core−Shell Microparticles for Embolization Purposes
2010; American Chemical Society; Volume: 11; Issue: 6 Linguagem: Inglês
10.1021/bm100251s
ISSN1526-4602
AutoresHagit Aviv, Bartling Soenke, Johannes Budjan, Shlomo Margel,
Tópico(s)Intracerebral and Subarachnoid Hemorrhage Research
ResumoCore P(MAOETIB-GMA) microparticles of 40−200 μm were prepared by suspension copolymerization of the iodinated monomer 2-methacryloyloxyethyl (2,3,5-triiodobenzoate), MAOETIB, with a low concentration of the monomer glycidyl methacrylate, GMA, which formed hydrophilic surfaces on the particles. Magnetic γ-Fe2O3/P(MAOETIB-GMA) core−shell microparticles were prepared by coating the aforementioned core particles through nucleation of iron oxide nanoparticles on the surfaces of the P(MAOETIB-GMA) particles. This was followed by stepwise growth of thin iron oxide layers. The radiopacity and magnetism of these particles were demonstrated in vitro by CT and MRI. In vivo embolization capabilities of these first multimodal visible embolization particles were demonstrated in a rat's kidney tumor embolization model.
Referência(s)