Vancomycin encapsulation in biodegradable poly(ε-caprolactone) microparticles for bone implantation. Influence of the formulation process on size, drug loading, in vitro release and cytocompatibility
2002; Elsevier BV; Volume: 24; Issue: 3 Linguagem: Inglês
10.1016/s0142-9612(02)00357-5
ISSN1878-5905
AutoresAnne‐Marie Le Ray, S Chiffoleau, P Iooss, G. Grimandi, Alain Gouyette, G. Daculsi, Christian Merle,
Tópico(s)Graphene and Nanomaterials Applications
ResumoVancomycin encapsulation in biodegradable poly(epsilon-caprolactone) microparticles (200 microm mean diameter) was most efficient with a simple emulsion technique that dispersed 122.5 mg/g of polymer. Scanning electron micrographs showed smooth or pitted particles. Dissolution studies were correlated with microparticle morphology, indicating higher release with pitted particles when vancomycin was encapsulated in a dissolved state. The cytocompatibility of these poly(epsilon-caprolactone) microparticles was demonstrated by a direct contact cytotoxic assay. This material can be considered as an efficient drug delivery system for bone implantation.
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