Tadalafil in Primary Pulmonary Arterial Hypertension
2004; American College of Physicians; Volume: 141; Issue: 9 Linguagem: Inglês
10.7326/0003-4819-141-9-200411020-00033
ISSN1539-3704
AutoresEmiliano A. Palmieri, Flora Affuso, Sergio Fazio, Danilo Lembo,
Tópico(s)Coagulation, Bradykinin, Polyphosphates, and Angioedema
ResumoLetters2 November 2004Tadalafil in Primary Pulmonary Arterial HypertensionEmiliano Antonio Palmieri, MD, Flora Affuso, MD, Serafino Fazio, MD, and Danilo Lembo, MDEmiliano Antonio Palmieri, MDFrom University Federico II Medical School, 80131 Naples, Italy, and Eli Lilly, 50019 Florence, Italy., Flora Affuso, MDFrom University Federico II Medical School, 80131 Naples, Italy, and Eli Lilly, 50019 Florence, Italy., Serafino Fazio, MDFrom University Federico II Medical School, 80131 Naples, Italy, and Eli Lilly, 50019 Florence, Italy., and Danilo Lembo, MDFrom University Federico II Medical School, 80131 Naples, Italy, and Eli Lilly, 50019 Florence, Italy.Author, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-141-9-200411020-00033 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail TO THE EDITOR:Background: Sildenafil, a short-acting phosphodiesterase-5 inhibitor (1), is safe and may benefit patients with primary pulmonary arterial hypertension (2-8). However, it requires many daily administrations. We describe a patient with end-stage primary pulmonary arterial hypertension who improved while taking tadalafil, a long-acting phosphodiesterase-5 inhibitor (9).Case Report: A 72-year-old woman was hospitalized for progressive cardiopulmonary failure. Five years earlier, primary pulmonary arterial hypertension was diagnosed and the patient was hospitalized for hydropic decompensation and hypoxemia. Since then, she had been receiving permanent oxygen therapy and had also taken digoxin, amlodipine, furosemide, potassium canrenoate, and acenocoumarol.At the ...References1. Cheitlin MD, Hutter AM, Brindis RG, Ganz P, Kaul S, Russell RO, et al . ACC/AHA expert consensus document. Use of sildenafil (Viagra) in patients with cardiovascular disease. American College of Cardiology/American Heart Association. J Am Coll Cardiol. 1999;33:273-82. [PMID: 9935041] CrossrefMedlineGoogle Scholar2. Prasad S, Wilkinson J, Gatzoulis MA. 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Efficacy and safety of tadalafil for the treatment of erectile dysfunction: results of integrated analyses. J Urol. 2002;168:1332-6. [PMID: 12352386] CrossrefMedlineGoogle Scholar Author, Article, and Disclosure InformationAffiliations: From University Federico II Medical School, 80131 Naples, Italy, and Eli Lilly, 50019 Florence, Italy. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetailsSee AlsoCombination Therapy with Oral Sildenafil and Inhaled Iloprost for Severe Pulmonary Hypertension Hossein Ardeschir Ghofrani , Ralph Wiedemann , Frank Rose , Horst Olschewski , Ralph Theo Schermuly , Norbert Weissmann , Werner Seeger , and Friedrich Grimminger Metrics Cited ByPharmacokinetic and Bioequivalence Evaluation of 2 Tadalafil Tablets in Healthy Male Chinese Subjects Under Fasting and Fed ConditionsThe Noncanonical Pathway for In Vivo Nitric Oxide Generation: The Nitrate-Nitrite-Nitric Oxide PathwaySafety and effectiveness of tadalafil in patients with pulmonary arterial hypertension: Japanese post-marketing surveillance dataEfficacy of sildenafil in HIV-related pulmonary arterial hypertensionOral Therapies for Pulmonary Arterial HypertensionTadalafil as monotherapy and in combination regimens for the treatment of pulmonary arterial hypertensionPortopulmonary hypertension: An updateLong-acting phosphodiesterase 5 inhibitor, tadalafil, and superoxide dismutase mimetic, tempol, protect against acute hypoxia-induced pulmonary hypertension in ratsReactive oxygen and nitrogen species in pulmonary hypertensionTadalafil for the treatment of pulmonary arterial hypertensionPulmonary hypertension—"state of the art" management in 2012Clinical Efficacy of Phosphodiesterase-5 Inhibitor Tadalafil in Eisenmenger Syndrome-A Randomized, Placebo-controlled, Double-blind Crossover StudyTadalafil: A Long-Acting Phosphodiesterase-5 Inhibitor for the Treatment of Pulmonary Arterial HypertensionTadalafil for the treatment of pulmonary arterial hypertensionHigh Altitude, A Natural Research Laboratory for the Study of Cardiovascular Physiology and PathophysiologyTadalafil for the treatment of pulmonary arterial hypertensionNon-congenital heart disease associated pediatric pulmonary arterial hypertensionTadalafil Therapy for Pulmonary Arterial HypertensionCyclic GMP signaling in cardiovascular pathophysiology and therapeuticsCombination therapy with prostacyclin and tadalafil for severe pulmonary arterial hypertension: A pilot studyTadalafil improves oxygenation in a model of newborn pulmonary hypertensionPharmacokinetic Interaction Between Tadalafil and Bosentan in Healthy Male SubjectsSustained benefit of tadalafil in patients with pulmonary arterial hypertension with prior response to sildenafil: A case series of 12 patientsMedical therapy for pulmonary arterial hypertensionCurrent Therapies for Pulmonary Arterial HypertensionThe Nitric Oxide/cGMP Signaling Pathway in Pulmonary HypertensionThe effects of chronic phosphodiesterase-5 inhibitor use on different organ systemsGoal-oriented treatment and combination therapy for pulmonary arterial hypertensionUse of Tadalafil for Treating Pulmonary Arterial Hypertension Secondary to Chronic Obstructive Pulmonary DiseasePharmacologic treatment for pulmonary arterial hypertensionEffet bénéfique du sildénafil en postopératoire dans le rétrécissement mitral compliqué d'hypertension artérielle pulmonaire précapillaire : à propos de deux casTadalafil improves quality of life and exercise tolerance in idiopathic pulmonary arterial hypertensionEfficacy of Oral Tadalafil, a New Long-acting Phosphodiesterase-5 Inhibitor, for the Short-term Treatment of Pulmonary Arterial Hypertension in a DogEXPERIMENTAL THERAPIES FOR HYPOXIA-INDUCED PULMONARY HYPERTENSION DURING ACUTE LUNG INJURYTadalafil: Pulmonary Hypertension (Adults)Drug Treatment of Pulmonary Arterial HypertensionPDE5 Inhibitors and the cGMP Pathway in Pulmonary Arterial Hypertension 2 November 2004Volume 141, Issue 9Page: 743-744KeywordsDiureticsEchocardiographyEdemaFraction of inspired oxygenHalf lifeHeartHeart rateOxygenPulmonary hypertensionSystolic pressure ePublished: 2 November 2004 Issue Published: 2 November 2004 CopyrightCopyright © 2004 by American College of Physicians. 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