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Drug transport via the intestinal peptide transporter PepT1

2013; Elsevier BV; Volume: 13; Issue: 6 Linguagem: Inglês

10.1016/j.coph.2013.08.004

1471-4973

Matthias Brandsch,

Pneumocystis jirovecii pneumonia detection and treatment

The focus of this review is on the pharmaceutical relevance of the intestinal peptide transporter PepT1. The review is limited to the progress made in the field over the past two years. Much of this progress is being driven by the prevailing view that PepT1 can be used for drug delivery purposes. Studies have indeed shown that several drugs, prodrugs and drug candidates gain entry into the systemic circulation via PepT1. Very recent examples are prodrugs of zanamivir, oseltamivir and didanosine.