Challenges of Making Music: What Causes Musician’s Dystonia?
2013; American Medical Association; Volume: 70; Issue: 11 Linguagem: Inglês
10.1001/jamaneurol.2013.3931
ISSN2168-6157
AutoresAlexander Schmidt, Hans‐Christian Jabusch, Eckart Altenmüller, Meike Kasten, Christine Klein,
Tópico(s)Neuroscience and Music Perception
ResumoMusician's dystonia, a task-specific movement disorder, affects 1% to 2% of professional musicians and is thought to be environmentally acquired, related to years of practice. 1,2Indeed, professional musicians will have spent more than 10 000 hours on the instrument by the age of 20 years. 3 Recently, a clustering of different types of dystonia was reported in the families of patients with musician's dystonia, suggesting also a genetic contribution to the disease. 4 However, the underlying molecular genetic factors are currently unknown.We here investigated in a case-control design whether intensive practice or other environmental factors are associated with musician's dystonia in combination with genetic susceptibility.Increased practice, No. (%) [95% CI] 33 (30) [22-39] 73 (74) [64-81] 16 (26) [17-39] Abbreviations: HFM, healthy family member (of patients with musician's dystonia); IMMM, Institute of Music Physiology and Musicians' Medicine; MHD, musician's hand dystonia; NA, not applicable.a 2-sided χ 2 test, P = .004.b 2-sided χ 2 test, P < .001.c For the 9 musicians.d 2-sided t test, P < .001.
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