Paraneoplastic “stiff person syndrome” with metastatic adenocarcinoma and anti-Ri antibodies
2004; Lippincott Williams & Wilkins; Volume: 62; Issue: 8 Linguagem: Inglês
10.1212/01.wnl.0000123694.64121.d5
ISSN1526-632X
AutoresDominick J. H. McCabe, Nicholas C. Turner, Debra T. Chao, Alexander Leff, Norman A. Gregson, Howard John Womersley, I. Tong Mak, G D Perkin, Anthony H.V. Schapira,
Tópico(s)Glycogen Storage Diseases and Myoclonus
ResumoA 43-year-old woman presented with clinical and electrophysiologic features of stiff person syndrome (SPS), without abdominal or lumbar paraspinal muscle involvement. Investigations revealed metastatic adenocarcinoma of the lung with positive anti-Ri antibodies. Her clinical condition improved with diazepam, baclofen, tizanidine, and palliative chemotherapy. Screening for an underlying malignancy and anti-Ri antibodies should be considered in patients with SPS when clinical presentation is atypical.
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