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A high incidence of vertebral fracture in women with breast cancer

1999; Springer Nature; Volume: 79; Issue: 7-8 Linguagem: Inglês

10.1038/sj.bjc.6690188

1532-1827

John А. Kanis, Eugène McCloskey, T.J. Powles, Alexander Paterson, S. Ashley, Tim D. Spector,

Medical Imaging Techniques and Applications

Because treatment for breast cancer may adversely affect skeletal metabolism, we investigated vertebral fracture risk in women with non-metastatic breast cancer. The prevalence of vertebral fracture was similar in women at the time of first diagnosis to that in an age-matched sample of the general population. The incidence of vertebral fracture, however, was nearly five times greater than normal in women from the time of first diagnosis [odds ratio (OR), 4.7; 95% confidence interval (95% CI), 2.3–9.9], and 20-fold higher in women with soft-tissue metastases without evidence of skeletal metastases (OR, 22.7; 95% CI, 9.1–57.1). We conclude that vertebral fracture risk is markedly increased in women with breast cancer.