Portal de Periódicos da CAPES

Identification of Six Taxine Alkaloids from Taxus baccata Needles

1996; American Chemical Society; Volume: 59; Issue: 2 Linguagem: Inglês

10.1021/np960033l

1520-6025

Louis H. D. Jenniskens, Erik L. M. van Rozendaal, Teris A. van Beek, Peter Wiegerinck, Hans W. Scheeren,

Chemical synthesis and alkaloids

Six taxine alkaloids were isolated from Taxus baccata needles and partially separated. An HPLC method for the analysis of the taxine fraction was developed. By NMR and deamination/hydrolysis studies it was established that the taxine fraction consisted mostly of taxicin-I and taxicin-II derivatives in a variable ratio. Four of the six taxine alkaloids isolated have not been reported before. All of the alkaloids were found to be unstable under neutral and basic conditions, and some of them were very easily interconverted.