Asymmetric synthesis of 1-hydroxyindolizidines, biosynthetic precursors to the toxic indolizidine alkaloids slaframine and swainsonine
1990; Elsevier BV; Volume: 1; Issue: 11 Linguagem: Inglês
10.1016/s0957-4166(00)80439-5
ISSN1362-511X
AutoresHiroki Takahata, Yasunori Banba, Takefumi Momose,
Tópico(s)Chemical synthesis and alkaloids
ResumoAn enantioselective synthesis of 1-hydroxyindolizidines (1 and 2) from racemic N-benzyloxycarbonyl-3-hydroxy-4-pentenylamine (3) by following the Sharpless kinetic resolution, intramolecular amidomercuration, and radical Michael addition as key steps is described.
Referência(s)