Portal de Periódicos da CAPES

NAD+ and sirtuins in aging and disease

2014; Elsevier BV; Volume: 24; Issue: 8 Linguagem: Inglês

10.1016/j.tcb.2014.04.002

1879-3088

Shin‐ichiro Imai, Leonard Guarente,

Adipose Tissue and Metabolism

Nicotinamide adenine dinucleotide (NAD + ) is a classical coenzyme mediating many redox reactions. NAD + also plays an important role in the regulation of NAD + -consuming enzymes, including sirtuins, poly-ADP-ribose polymerases (PARPs), and CD38/157 ectoenzymes. NAD + biosynthesis, particularly mediated by nicotinamide phosphoribosyltransferase (NAMPT), and SIRT1 function together to regulate metabolism and circadian rhythm. NAD + levels decline during the aging process and may be an Achilles' heel, causing defects in nuclear and mitochondrial functions and resulting in many age-associated pathologies. Restoring NAD + by supplementing NAD + intermediates can dramatically ameliorate these age-associated functional defects, counteracting many diseases of aging, including neurodegenerative diseases. Thus, the combination of sirtuin activation and NAD + intermediate supplementation may be an effective antiaging intervention, providing hope to aging societies worldwide.