Hypoparathyroidism and elevated muscle enzymes
1980; Lippincott Williams & Wilkins; Volume: 30; Issue: 2 Linguagem: Inglês
10.1212/wnl.30.2.192
ISSN1526-632X
AutoresElizabeth Shane, Kenneth A. McClane, Marcelo R. Olarte, John P. Bilezikian,
Tópico(s)Genetic Syndromes and Imprinting
ResumoWe studied a patient with hypocalcemia and increased serum activity of sarcoplasmic enzymes. Idiopathic hypoparathyroidism was established by history, low serum parathyroid hormone content, and marked responsiveness of urinary cyclic AMP and phosphate to parathyroid hormone. Muscle-associated isoenzymes of creatine phosphokinase and lactic dehydrogenase were increased, but there was no concomitant muscle weakness. Muscle biopsy was normal by morphologic and histochemical examination. The patient was treated with calcium and vitamin D. As the calcium rose, there were corresponding decreases in the serum activities of creatine phosphokinase and lactic dehydrogenase, with correlation coefficients of -0.88 and -0.64, respectively ( p ≤ 0.01).
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