Produção Nacional
In vitro and in vivo safety evaluation of Dipteryx alata Vogel extract
2012; BioMed Central; Volume: 12; Issue: 1 Linguagem: Inglês
10.1186/1472-6882-12-9
ISSN1472-6882
AutoresNatália Mencacci Esteves-Pedro, Thaisa Borim, Virgínia Sbrugnera Nazato, Magali Glauzer Silva, Patrícia Santos Lopes, Márcio Galdino dos Santos, Cháriston André Dal Belo, Cássia Regina Cardoso, Eliana Aparecida Varanda, Francisco Carlos Groppo, Marli Gerenutti, Yoko Oshima‐Franco,
Tópico(s)Plant Toxicity and Pharmacological Properties
ResumoAbstract Background Dipteryx alata Vogel popularly known as "baru" is an important commercial leguminous tree species from the Brazilian Cerrado, which possess medicinal properties, besides its fruits consumption by animals and humans. The use of the "naturally occurring plants" as herbal remedies and foods mainly from leaves, seeds, flowers and roots of plants or extracts require precautions before ensuring these are safe and efficacious. The objective of this study was to evaluate the safety of D. alata barks extract. Methods Vegetal drugs of D. alata barks were submitted to quality control assays and further to the safety assays under 1) in vitro parameter by Salmonella (Ames) mutagenicity, and 2) in vivo parameter on the pregnancy of rats. Results The extract was non-mutagenic to any of the assessed strains TA97a, TA98, TA100 and TA102 even after metabolic activation (+S9). All in vivo parameters (reproductive ability evaluation, physical development of rat offsprings, and neurobehavioral development assays) showed no changes related to control group. Conclusion D. alata barks extract is neither mutagenic by the Ames test nor toxic in the pregnancy of rats, with no physical-neurobehavioral consequences on the rat offsprings development.
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