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Patient and graft outcomes from older living kidney donors are similar to those from younger donors despite lower GFR

2004; Elsevier BV; Volume: 66; Issue: 4 Linguagem: Inglês

10.1111/j.1523-1755.2004.00932.x

1523-1755

Lourdes S. Peña de la Vega, Alvaro Torres, Humberto Bohórquez, Julie K. Heimbach, James M. Gloor, Thomas R. Schwab, Sandra J. Taler, Scott L. Nyberg, Michael B. Ishitani, Mikel Prieto, Jorge A. Velosa, Timothy S. Larson, Mark D. Stegall, Fernando G. Cosio, Stephen C. Textor, Matthew D. Griffin,

Organ Transplantation Techniques and Outcomes

Donor age adversely affects deceased-donor kidney transplant outcomes, but its influence on living-donor transplantation is less well characterized.Living-donor kidney transplants at a single center between 1998 and 2000 were reviewed. Data were abstracted for 52 transplants from donors aged > or =50 years and for a matched group of 104 transplants from donors aged or =90% for both groups. At 1, 12, and 24 months, serum creatinine was higher and GFR was lower among recipients of older- compared with younger-donor grafts. Other functional indices (urine total protein, serum potassium and uric acid, hemoglobin, and number of antihypertensives) were not different. Donor age correlated with graft GFR at 1, 12, and 24 months for the entire study cohort by linear regression.Older donor age does not preclude excellent results from living-donor kidney transplantation but should be appreciated as being associated with relatively lower GFR.