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Neoflavonoids and Related Constituents from Nepalese Propolis and Their Nitric Oxide Production Inhibitory Activity

2005; American Chemical Society; Volume: 68; Issue: 6 Linguagem: Inglês

10.1021/np050009k

1520-6025

Suresh Awale, Suraj Prakash Shrestha, Yasuhiro Tezuka, Jun‐ya Ueda, Katsumichi Matsushige, Shigetoshi Kadota,

Essential Oils and Antimicrobial Activity

A methanolic extract of Nepalese propolis yielded 10 new open-chain neoflavonoids (1−10), a new chalcone (11), and eight previously reported compounds (12−19). Their structures were determined on the basis of spectroscopic data and chemical conversion. The isolated compounds other than 5, 8, and 16 showed dose-dependent inhibitory activities on nitric oxide production in lipopolysaccharide-activated macrophage-like J774.1 cells and were more active than a positive control, NG-monomethyl-l-arginine (IC50, 27.1 μM). The most potent activities, of 6 and 7 (IC50, 0.5 μM), were greater than another positive control, caffeic acid phenethyl ester (IC50, 4.8 μM).