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Chimerism of the Transplanted Heart

2002; Massachusetts Medical Society; Volume: 346; Issue: 1 Linguagem: Inglês

10.1056/nejmoa012081

1533-4406

Federico Quaini, Konrad Urbanek, Antonio Paolo Beltrami, Nicoletta Finato, Carlo Alberto Beltrami, Bernardo Nadal‐Ginard, Jan Kajstura, Annarosa Leri, Piero Anversa,

Congenital heart defects research

Cases in which a male patient receives a heart from a female donor provide an unusual opportunity to test whether primitive cells translocate from the recipient to the graft and whether cells with the phenotypic characteristics of those of the recipient ultimately reside in the donor heart. The Y chromosome can be used to detect migrated undifferentiated cells expressing stem-cell antigens and to discriminate between primitive cells derived from the recipient and those derived from the donor.