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Bioactive Silicate Nanoplatelets for Osteogenic Differentiation of Human Mesenchymal Stem Cells

2013; Volume: 25; Issue: 24 Linguagem: Inglês

10.1002/adma.201300584

1521-4095

Akhilesh K. Gaharwar, Silvia M. Mihăilă, Archana Swami, Alpesh Patel, Shilpa Sant, Rui L. Reis, Alexandra P. Marques, Manuela E. Gomes, Ali Khademhosseini,

biodegradable polymer synthesis and properties

Novel silicate nanoplatelets that induce osteogenic differentiation of human mesenchymal stem cells (hMSCs) in the absence of any osteoinductive factor are reported. The presence of the silicate triggers a set of events that follows the temporal pattern of osteogenic differentiation. These findings underscore the potential applications of these silicate nanoplatelets in designing bioactive scaffolds for musculoskeletal tissue engineering.