A novel chromium trioxide catalyzed oxidation of primary alcohols to the carboxylic acids
1998; Elsevier BV; Volume: 39; Issue: 30 Linguagem: Inglês
10.1016/s0040-4039(98)00987-3
ISSN1873-3581
AutoresMangzhu Zhao, Jing Li, Zhiguo J. Song, Richard Desmond, David M. Tschaen, Edward J. J. Grabowski, Paul J. Reider,
Tópico(s)Catalysis and Oxidation Reactions
ResumoA novel CrO3 catalyzed oxidation of primary alcohols to the carboxylic acids is reported. The oxidation proceeds smoothly with only 1–2 mol % of CrO3 and 2.5 equivalents of H5IO6 in wet MeCN to give the carboxylic acids in excellent yield. No significant racemization is observed for alcohols with adjacent chiral centers. Secondary alcohols are cleanly oxidized to ketones.
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