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THE USE OF PARA-AMINOBENZOIC ACID IN ENDEMIC (MURINE) TYPHUS

1946; American Medical Association; Volume: 131; Issue: 14 Linguagem: Inglês

10.1001/jama.1946.02870310010003

2376-8118

Paul K. Smith,

Insect Pest Control Strategies

Evidence gradually is accumulating that para-aminobenzoic acid is effective in experimental infections induced by several types of rickettsial organisms. Studies on yolk sacs infected with Rickettsia prowazeki (epidemic typhus) 1 have shown that para-aminobenzoic acid is reasonably effective in inhibiting the growth of the organisms. A similar effect was observed when penicillin was used. 2 Under the same circumstances para-aminobenzoic acid was remarkably effective in eggs infected with Rickettsia mooseri (murine typhus). 1 The organisms of spotted fever (Rickettsia rickettsii) were inhibited in chick embryos 3 even more easily than were the organisms of murine typhus. On the other hand, there was no appreciable effect on Rickettsia orientalis. 3 An inhibitory effect was also observed in guinea pigs infected with R. rickettsii. 4 Experimental infections of rodents with R. orientalis were amenable to therapy with para-aminobenzoic acid when the drug was given by simultaneous oral and parenteral administration. 5 Clinically,