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Identification of Galectin-3 and Mucin-Type O-Glycans in Breast Cancer and Its Metastasis to Brain

2008; Taylor & Francis; Volume: 26; Issue: 6 Linguagem: Inglês

10.1080/07357900701837051

1532-4192

Miguel Ángel Mayoral, C. Mayoral, Antônio Carlos Oliveira Meneses, Leonardo Villalvazo, A. Guzmán, Blanca Espinosa, José Luís Ochoa, Edgar Zenteno, Jorge Guevara,

Microbial Metabolites in Food Biotechnology

Galectin-3 has been implicated in tumor progression. We demonstrated immunohistochemically that Galectin-3 was negative in normal breast tissue, but it was highly increased in breast cancer and in metastatic tissues to brain. Similarly, histochemistry with mucin-specific lectins showed increased recognition in breast tumor and metastasis with Machaerocereus eruca agglutinin (Fuα 1,2 (GalNAcα 1,3) Galß1,4 in complex mucin) but not for Amaranthus leucocarpus (Galß1,3-GalNAc-α 1,0-Ser/Thr) and Arachis hypogaea lectins (Galß1,3GalNAc/Galß1,4GlcNAc). Mucin-type glycans and Galectin-3 colocalized in breast cancer and metastasis, but not in normal tissue, suggesting upregulated biosynthesis of complex O-glycosidically linked glycans and Galectin-3 favor breast cancer progression and brain metastasis.