Auricular microelectrostimulation: Naloxone-reversible attenuation of opiate abstinence syndrome
1988; Elsevier BV; Volume: 24; Issue: 8 Linguagem: Inglês
10.1016/0006-3223(88)90223-5
ISSN1873-2402
AutoresDavid H. Malin, Janie B. Murray, Gregory P. Crucian, F. C. Schweitzer, Robin E. Cook, Malcolm H. Skolnick,
Tópico(s)Vagus Nerve Stimulation Research
ResumoAbstract This study evaluated the effects in rats of very low amplitude (10 μamp) charge-balanced 10-Hz stimulation delivered bilaterally to low impedance points on the outer ear. This microelectrostimulation markedly and significantly reduced the number of opiate abstinence signs observed following a week of continuous morphine infusion. This effect was prevented by subcutaneous injection of 3 mg/kg naloxone, suggesting that stimulation of endogenous opioid activity plays a major role in the actions of auricular microelectro-stimulation.
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