Voltar
Artigo Acesso aberto Produção Nacional
BIBTEX RIS

Pleomorphic Adenoma of the Submandibular Gland

2002; American Medical Association; Volume: 128; Issue: 12 Linguagem: Inglês

10.1001/archotol.128.12.1400

ISSN

1538-361X

Autores

Fábio Abreu Alves, Daniel E. C. Perez, Osley P. Almeida, Márcio Ajudarte Lopes, Luiz Paulo Kowalski,

Tópico(s)

Oral and Maxillofacial Pathology

Resumo

The submandibular gland is involved in only 5% to 10% of the salivary gland tumors, and pleomorphic adenoma (PA) is the most common tumor affecting it. This study describes the clinicopathological features and immunohistochemical expression of Ki-67 and p53 in 60 cases of submandibular salivary gland PAs. Most of the patients were in the third and fifth decades of life and 37 (62%) of them were women. Tumor sizes varied from 1 to 10 cm and the mean time between symptom onset and treatment was 52 months. Only 1 patient experienced local recurrence, 3 years after treatment. Histologically, most tumors consisted chiefly in a chondromyxoid stroma. Stroma-rich PAs were larger than stroma-poor ones ( P <.02). All PAs were found negative for Ki-67 and p53. These results show that PAs of the submandibular gland are histologically similar to PAs of other salivary glands, and that they have a low proliferative rate and a good prognosis.

Referência(s)