Manifestations of the major gene influencing sucrose octaacetate (SOA) tasting among mice: classic taste qualitites
1990; Oxford University Press; Volume: 15; Issue: 3 Linguagem: Inglês
10.1093/chemse/15.3.243
ISSN1464-3553
AutoresGlayde Whitney, John C. Maggio, David B. Harder,
Tópico(s)Olfactory and Sensory Function Studies
ResumoAmong mice the autosomal gene Soa has a major effect on aversion to the bitter tastant sucrose octaacetate (SOA). The influence of the Soa locus on responsiveness to other tastants was investigated by comparing three strains of laboratory mice: B6, an inbred strain which carries the Soab allele (SOA taste blind); SW, an inbred strain which carries the Soaa allele (SOA aversion); and B6.SW- Soaa , mice congenic with B6 but carrying a chromosome segment bearing the Soaa allele which was transferred from the SW strain into the B6 line. Eighteen tastants (60 tastant concentrations) representing the classic taste qualities were tested. With the single exception of 10 mM acetic acid, the Soaa allele did not influence responsiveness to compounds which humans generally classify as sweet, sour, or salty. The Soaa allele did affect response to four of six bitter compounds. Among bitters, only quinine (QSO4 and QHCI) did not reveal an Soaa influence. Any Soaa allele influence on quinine tasting may be obscured among these mice because both the B6 and SW progenitor inbred strains display a rather strong aversion to quinine. The physiological mechanism(s) affected by the Soa locus may influence response to a broad range of generally bitter tastants.
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