Value of Deoxyribonucleic Acid Ploidy and Nuclear Morphometry for Prediction of Disease Progression in Renal Cell Carcinoma
1996; Lippincott Williams & Wilkins; Volume: 155; Issue: 2 Linguagem: Inglês
10.1016/s0022-5347(01)66418-8
ISSN1527-3792
AutoresJ.L. Ruiz-Cerdá, Miguel Ángel Ibáñez-Hernández, F Gomis, C.D. Vera Donoso, Bruce F. Kimler, José‐Enrique O’Connor, F. Jiménez-Cruz,
Tópico(s)Cancer Genomics and Diagnostics
ResumoNo AccessJournal of UrologyClinical Urology: Original Article1 Feb 1996Value of Deoxyribonucleic Acid Ploidy and Nuclear Morphometry for Prediction of Disease Progression in Renal Cell Carcinoma Jose L. Ruiz-Cerda, Miguel Hernandez, Federico Gomis, Cesar D. Vera, Bruce F. Kimler, J. Enrique O'Connor, and Fernando Jimenez-Cruz Jose L. Ruiz-CerdaJose L. Ruiz-Cerda More articles by this author , Miguel HernandezMiguel Hernandez More articles by this author , Federico GomisFederico Gomis More articles by this author , Cesar D. VeraCesar D. Vera More articles by this author , Bruce F. KimlerBruce F. Kimler More articles by this author , J. Enrique O'ConnorJ. Enrique O'Connor More articles by this author , and Fernando Jimenez-CruzFernando Jimenez-Cruz More articles by this author View All Author Informationhttps://doi.org/10.1016/S0022-5347(01)66418-8AboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookLinked InTwitterEmail Abstract Purpose: A retrospective study was performed on 108 patients with localized renal cell carcinoma (pT1 to 3a N0M0) to determine whether ploidy and nuclear morphometry are independent predictive factors in addition to stage and grade. Materials and Methods: Deoxyribonucleic acid (DNA) content was analyzed by flow cytometry and nuclear morphometry characterized by 5 nuclear descriptors. A Cox proportional hazards regression model was used to identify significant prognostic factors for disease progression. Results: A model combining tumor stage and grade, DNA ploidy and nuclear minor axis was chosen as optimal with risk of disease progression increased with increasing tumor stage and grade, DNA aneuploidy and increasing nuclear minor axis. Conclusions: This improved ability to predict disease progression in localized renal cell carcinoma may have important clinical use. References 1 : Clinical Flow Cytometry: Principles and Applications. Baltimore: Williams & Wilkins1993: 1. Google Scholar 2 : Urological cancers. In: Clinical Flow Cytometry: Principles and Applications. Edited by . Baltimore: Williams & Wilkins1993: 271. Google Scholar 3 : Nuclear morphometry as an important prognostic factor in stage I renal cell carcinoma. Cancer1986; 58: 2512. Google Scholar 4 : Nuclear shape analysis for assessment of prognosis in renal cell carcinoma. J. Urol.1990; 143: 1103. Link, Google Scholar 5 : Nuclear morphometry in prognosis of renal adenocarcinoma. Urology1992; 39: 130. Google Scholar 6 : Prognostic significance of morphologic parameters in renal cell carcinoma. Amer. J. Surg. Path.1982; 6: 655. Google Scholar 7 : Application of DNA flow cytometry to paraffin-embedded archival material for the study of aneuploidy and its clinical significance. Cytometry1985; 6: 327. Google Scholar 8 : Flow microfluorometric analysis of nuclear DNA in cells from solid tumors and cell suspensions. A new method for rapid isolation and straining of nuclei. Virchows Arch.. Cell Path.1977; 24: 227. Google Scholar 9 : DNA content in renal cell carcinoma with reference to tumor heterogeneity. Cancer1985; 56: 503. Google Scholar 10 : Renal cell carcinoma. A clinicopathologic and DNA flow cytometric analysis of 103 cases. Cancer1989; 64: 2133. Google Scholar 11 : Flow cytometric assessment of deoxyribonucleic acid content in renal adenocarcinoma: does ploidy status enhance prognostic stratification over stage alone?. J. Urol.1990; 143: 458. Link, Google Scholar 12 : Ploidy and prognosis in renal carcinoma. Brit. J. Urol.1993; 71: 21. Google Scholar 13 : Well differentiated clear cell renal carcinoma: significance of nuclear deoxyribonucleic acid patterns studied by flow cytometry. J. Urol.1987; 137: 15. Link, Google Scholar 14 : Quantitative DNA analysis of small renal cortical neoplasms. Hum. Path.1991; 22: 247. Google Scholar 15 : Localized renal cell carcinoma treated by radical nephrectomy. Influence of pathologic data and the importance of DNA ploidy pattern on disease outcome. Cancer1993; 72: 2207. Google Scholar 16 : Flow cytometric analysis of nuclear DNA content of renal cell carcinoma correlated with histologic and clinical features. Cancer1993; 72: 1319. Google Scholar 17 : DNA flow cytometry as a predictor of outcome of stage I renal cell carcinoma. Cancer1989; 63: 1161. Google Scholar 18 : Flow cytometric deoxyribonucleic acid analysis in stage I renal cell carcinoma. J. Urol.1991; 146: 697. Link, Google Scholar 19 : Flow cytometric deoxyribonucleic acid analysis of primary and metastatic human renal cell carcinoma. J. Urol.1985; 133: 582. Link, Google Scholar 20 : Karyometry and histometry of renal-cell carcinoma. Anal. Quant. Cytol.. Histol.1987; 9: 182. Google Scholar 21 : The value of histoquantitative measurements in prognostic assessment of renal adenocarcinoma. Int. J. Cancer1993; 55: 547. Google Scholar 22 : Nuclear morphometry accurately predicts recurrence in clinically localized renal cell carcinoma. Urology1993; 42: 243. Google Scholar 23 : Nuclear planimetry in renal-cell tumors. Anal. Quant. Cytol.. Histol.1991; 13: 54. Google Scholar 24 : Value of volume weighted mean nuclear volume in grading and prognosis of renal cell carcinoma. J. Clin. Path.1994; 47: 324. Google Scholar 25 : Nuclear grading of renal cell carcinomas--is morphometry necessary?. J. Cancer Res. Clin. Oncol.1991; 117: 73. Google Scholar 26 : Prognostic factors in renal cancer. Urol. Clin. N. Amer.1993; 20: 247. Google Scholar Departments of Urology, Pathology and Hematology, La Fe University Hospital and Flow Cytometry Reference Center, Faculty of Medicine, University of Valencia, Valencia, Spain, and Department of Radiation Oncology, University of Kansas Medical Center, Kansas City, Kansas.© 1996 by American Urological Association, Inc.FiguresReferencesRelatedDetailsCited byMINERVINI A, DI CRISTOFANO C, COLLECCHI P, SALINITRI G, SELLI C, BEVILACQUA G, MINERVINI R and CAVAZZANA A (2018) INTRACAPSULAR CLEAR CELL RENAL CARCINOMA: PLOIDY STATUS IMPROVES THE PROGNOSTIC VALUE OF THE 2002 TNM CLASSIFICATIONJournal of Urology, VOL. 174, NO. 4 Part 1, (1203-1207), Online publication date: 1-Oct-2005. Volume 155Issue 2February 1996Page: 459-465 Advertisement Copyright & Permissions© 1996 by American Urological Association, Inc.MetricsAuthor Information Jose L. Ruiz-Cerda More articles by this author Miguel Hernandez More articles by this author Federico Gomis More articles by this author Cesar D. Vera More articles by this author Bruce F. Kimler More articles by this author J. Enrique O'Connor More articles by this author Fernando Jimenez-Cruz More articles by this author Expand All Advertisement PDF downloadLoading ...
Referência(s)