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Synthesis, blood compatibility and gas permeability of copolypeptides containing fluoroalkyl side groups

1988; Elsevier BV; Volume: 10; Issue: 4 Linguagem: Inglês

10.1016/0141-8130(88)90049-9

1879-0003

Yoshihiro Ito, Keiji Iwata, Inn‐Kyu Kang, Yukio Imanishi, Masahiko Sisido,

Membrane Separation and Gas Transport

Copolypeptides carrying long fluoroalkyl side chains were synthesized by the copolymerization of γ-benzyll-glutamate NCA and γ-fluoroalkyll-glutamate NCA. The fluoroalkyl side chains in the copolypeptides tended to appear on the air-side surface during film casting and made it very hydrophobic. By increasing the content of fluoroalkyl groups, the increased antithrombogenicity, the prolonged plasma recalcification time, the suppression of denaturation of plasma proteins upon adsorption, and the suppression of adhesion and activation of platelets were attained. These changes were ascribed to a low interaction of the inactive surface of copolypeptide film with biological components. The permeation of dissolved oxygen through the copolypeptide films reached 26-fold of that through poly(γ-benzyll-glutamate). The improved permeability is due either to the increased solubility of oxygen into fluoroalkylated polypeptide films or to the increased diffusion of oxygen through the layer of packed molecular chains which was loosened by the introduction of fluoroalkyl groups.