One-pot three-component reaction providing 1,5-benzodiazepine derivatives
2008; Elsevier BV; Volume: 64; Issue: 49 Linguagem: Inglês
10.1016/j.tet.2008.09.076
ISSN1464-5416
AutoresKenichi Murai, Ryo Nakatani, Yasuyuki Kita, Hiromichi Fujioka,
Tópico(s)Synthesis and biological activity
ResumoThe novel one-pot three-component reaction of aromatic aldehydes, 1,2-phenylenediamine, and β-keto esters is described. This reaction involves the γ-selective C–C bond formation of β-keto esters and produces 1,5-benzodiazepine derivatives.
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