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Analysis of the Calculated Physicochemical Properties of Respiratory Drugs: Can We Design for Inhaled Drugs Yet?

2009; American Chemical Society; Volume: 49; Issue: 4 Linguagem: Inglês

10.1021/ci800429e

1549-960X

Timothy J. Ritchie, Christopher N. Luscombe, Simon J. F. Macdonald,

Pharmacological Effects and Assays

From an analysis of calculated physicochemical properties for 81 currently marketed respiratory drugs, compounds administered via the inhaled/intranasal routes have a higher polar surface area, a higher molecular weight, and a trend toward lower lipophilicity, when compared with their orally administered counterparts. Ranges of physicochemical space are described for the 29 drugs administered by the inhaled or intranasal routes.