Dapsone-Induced Hemolysis in G6PD Deficiency
1967; American Medical Association; Volume: 201; Issue: 7 Linguagem: Inglês
10.1001/jama.1967.03130070074028
ISSN1538-3598
Autores Tópico(s)Erythrocyte Function and Pathophysiology
ResumoProfound hemolytic anemia developed in three glucose 6-phosphate dehydrogenase (G6PD)-deficient males while they were receiving 25 mg of dapsone (diaphenylsulfone) daily as prophylaxis for falciparum malaria. This suggests that, in some susceptible individuals, the hemolytic threshold for dapsone is lower than the 50 mg daily previously reported. Either individual variation in the degree of erythrocyte G6PD deficiency or concurrent administration of other potentially hemolytic drugs or both may account for this fact.
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