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BIBTEX RIS

Analysis of the association between Epstein-Barr virus and classic Hodgkin’s lymphoma in adult patients from Ceará (Brazil) by immunohistochemistry and in situ hybridization

2006; Sociedade Brasileira de Patologia Clínica; Volume: 42; Issue: 3 Linguagem: Inglês

10.1590/s1676-24442006000300009

ISSN

1678-4774

Autores

Marília Taumaturgo Pinto, Francisco Valdeci de Almeida Ferreira, Maria da Silva Pitombeira, Sílvia Maria Meira Magalhães, Clara Maria Bastos Eloy da Costa, Paulo Wagner Linhares Lima Filho, Renata Praciano Correia Férrer, Andrei Levine Porfírio de Aguiar, Francisco Dário Rocha Filho,

Tópico(s)

Eosinophilic Disorders and Syndromes

Resumo

The prevalence of Epstein-Barr virus (EBV) in patients with classical Hodgkin's lymphoma (CHL) is geographically variable. In the present study the prevalence of EBV in CHL was assessed in adult patients from Ceará, Brazil. Thirty-seven cases were immunohistochemically evaluated for EBV using latent membrane protein (LMP1) antibody and for EBV latency-associated RNA (EBER1) using in situ hybridization (ISH). Sex and age did not differ among patients as to the frequency of CHL. Nodular sclerosis was the predominant histological subtype. LMP1 was found in Reed-Sternberg cells in 67.5% of the cases whereas ISH detected EBER1 in 75.6%. Regarding histological subtypes EBV infection rates were not found statistically different in nodular sclerosis (NS) and mixed cellularity (MC) subtypes (p = 0.66).

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