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Square-wave voltammetry applied to the totally irreversible reduction of adsorbate

1993; Elsevier BV; Volume: 345; Issue: 1-2 Linguagem: Inglês

10.1016/0022-0728(93)80485-z

1873-2569

John J. O’Dea, Alvaro Ribes, Janet Osteryoung,

Analytical Chemistry and Sensors

The totally irreversible reduction of adsorbed material is studied by square-wave voltammetry. The model compound chosen is midazolam, 8-chloro-6-(2-fluorophenyl)-1-methyl-4H-imidazo[1,5-a][1,4]benzodiazepine. Experimental voltammograms are compared directly with the exact numerical solution for the boundary value problem via COOL, a numerical method yielding estimates of transfer coefficient and rate constant for the process. The agreement between experimental and calculated voltammograms is excellent over a wide of experimental conditions. Artifacts of measurement such as uncompensated solution resistance are readily detected. The limitations of previous empirical descriptions of the response are shown by comparison with these results.