
Developing T‐cell migration: role of semaphorins and ephrins
2012; Wiley; Volume: 26; Issue: 11 Linguagem: Inglês
10.1096/fj.11-202952
ISSN1530-6860
AutoresDaniella Arêas Mendes‐da‐Cruz, Marco Augusto Stimamiglio, Juan José Múñoz, David Alfaro, Eugênia Terra‐Granado, Javier García‐Ceca, Luis Miguel Alonso‐Colmenar, Wilson Savino, A. Zapata,
Tópico(s)Angiogenesis and VEGF in Cancer
ResumoCell migration is a crucial event for normal T-cell development, and various ligand/receptor pairs have been implicated. Most of them, including chemokines and extracellular matrix proteins, have attractant properties on thymocytes. We discuss herein two further groups of ligand/receptor pairs, semaphorins/neuropilins and ephs/ephrins, which are constitutively expressed by thymocytes and thymic microenvironmental cells. Evidence shows that the corresponding interactions are relevant for developing T-cell migration, including the entry of bone marrow progenitor cells, migration of CD4/CD8-defined thymocyte subpopulations triggered by chemokines and/or extracellular matrix proteins, and thymocyte export. Conceptually, the data summarized here show that thymocyte migration results from a complex network of molecular interactions, which generate not only attraction, but also repulsion of migrating T-cell precursors.—Mendes-da-Cruz, D. A., Stimamiglio, M. A., Muñoz, J. J., Alfaro, D., Terra-Granado, E., Garcia-Ceca, J., Alonso-Colmenar, L. M., Savino, W., Zapata, A. G. Developing T-cell migration: role of semaphorins and ephrins. FASEB J. 26, 4390–4399 (2012). www.fasebj.org
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