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An alumina column 82Rb generator

1979; Pergamon Press; Volume: 30; Issue: 6 Linguagem: Inglês

10.1016/0020-708x(79)90026-7

1878-1284

Y. Yano, Eugene P. Roth,

Medical Imaging and Pathology Studies

The use of an alumina column for the adsorption of radioactive Sr for the generator production of 75-s 82Rb was evaluated in both batch and column experiments using commercially available 85Sr and cyclotron-produced 82Sr. Comparisons of alumina, Bio-Rex 70 and Chelex 100 ion exchangers were made to determine Sr adsorption, 82Rb elution yield and Sr breakthrough. The adsorption of Sr is similar for alumina and Chelex 100 but different for Bio-Rex 70. Alumina and Chelex 100 have a higher breakthrough of Sr in the early elution volumes. After continued elution with 200–300 ml of solution the breakthrough of 82Sr decreases and remains stable at a lower breakthrough value through a large number of elutions. However, with Bio-Rex 70 the breakthrough of 82Sr remains the lowest of the three ion exchangers in the early elution volumes and remains low through a moderate number of elutions after which Sr breakthrough begins to increase steadily. The alumina-column 82Rb generator was found to be superior to Bio-Rex 70 or Chelex 100 for low breakthrough of 82Sr after many elutions of 82Rb with up to 3.1. of eluent solution.