First-trimester screening for Down syndrome using nuchal translucency measurement with free β-hCG and PAPP-A between 10 and 13 weeks of pregnancy—the combined test
1999; Wiley; Volume: 19; Issue: 4 Linguagem: Inglês
10.1002/(sici)1097-0223(199904)19
ISSN1097-0223
AutoresPierangela De Biasio, Marco A. Siccardi, G. Volpe, L Famularo, Francesca De Santi, Silvana Canini,
Tópico(s)Congenital Anomalies and Fetal Surgery
ResumoIn a population of 1467 women attending the 'G. Gaslini' Institute for antenatal care, we evaluated first-trimester risk screening for Down syndrome using the 'combined test' based on ultrasound measurement of nuchal translucency (NT), maternal serum pregnancy-associated plasma protein A (PAPP-A) and free β-hCG, and maternal age. No clinical action was taken on these results. The gestational age, determined by scan measurement of crown–rump length, ranged from 10 weeks to 13 weeks 6 days. The median maternal age was 31 years 8 months. There were 13 Down syndrome pregnancies. The risk of having an affected pregnancy was estimated from a multivariate Gaussian distribution, using commercially available software. With a risk cut-off of 1 in 350, 11 affected pregnancies were detected (detection rate 85 per cent, 95 per cent confidence interval: 56–100 per cent) with a 3.3 per cent false-positive rate. The odds of being affected given a positive result were 1 in 30. Further data are needed to determine, with greater statistical reliability, the relative performance of the combined test with current second-trimester screening. Copyright © 1999 John Wiley & Sons, Ltd.
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