Mechanisms of Exercise Intolerance in Heart Failure With Preserved Ejection Fraction
2013; Japanese Circulation Society; Volume: 78; Issue: 1 Linguagem: Inglês
10.1253/circj.cj-13-1103
ISSN1347-4820
Autores Tópico(s)Heart Failure Treatment and Management
ResumoApproximately half of patients with heart failure (HF) have a preserved ejection fraction (HFpEF), and with the changing age and comorbidity characteristics in the adult population, this number is growing rapidly. The defining symptom of HFpEF is exercise intolerance, but the specific mechanisms causing this common symptom remain debated and inadequately understood. Although diastolic dysfunction was previously considered to be the sole contributor to exercise limitation, recent studies have identified the importance of ventricular systolic, chronotropic, vascular, endothelial and peripheral factors that all contribute in a complex and highly integrated fashion to produce the signs and symptoms of HF. This review will explore the mechanisms underlying objective and subjective exercise intolerance in patients with HFpEF. (Circ J 2014; 78: 20–32)
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