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Neurocognitive Functioning in Pediatric Human Immunodeficiency Virus Infection

2005; American Medical Association; Volume: 159; Issue: 7 Linguagem: Inglês

10.1001/archpedi.159.7.651

1538-3628

Manisha C. Shanbhag, Richard M. Rutstein, Theoklis Zaoutis, Huaqing Zhao, David Vai Kiong Chao, Jerilynn Radcliffe,

Cytomegalovirus and herpesvirus research

Objectives: To assess the impact of combination antiretroviral therapy on neurocognitive outcomes in perinatally human immunodeficiency virus (HIV)-infected patients and to determine if CD4 percentage and plasma HIV-1 RNA level (viral load) are predictive of future neurocognitive function.Design: Retrospective cohort study.Setting: An HIV-dedicated urban care center.Participants: One hundred forty-six perinatally HIVinfected children born between June 1990 and May 2003 with at least 1 neurocognitive evaluation.Main Outcome Measures: Neurocognitive standard testing scores as well as diagnosis of progressive encephalopathy, probable progressive encephalopathy, or static encephalopathy. Results:The prevalence of progressive encephalopathy has decreased in children born prior to 1996 (period 1) compared with those born after 1996 (period 2) from 29.6% to 12.1% (P=.049).The prevalence of all pro-