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Nanoparticle Characterization: State of the Art, Challenges, and Emerging Technologies

2013; American Chemical Society; Volume: 10; Issue: 6 Linguagem: Inglês

10.1021/mp300697h

1543-8392

Eun Jung Cho, Hillary Holback, C. Karen Liu, Sara A. Abouelmagd, Joonyoung Park, Yoon Yeo,

Advanced Drug Delivery Systems

Nanoparticles have received enormous attention as a promising tool to enhance target-specific drug delivery and diagnosis. Various in vitro and in vivo techniques are used to characterize a new system and predict its clinical efficacy. These techniques enable efficient comparison across nanoparticles and facilitate a product optimization process. On the other hand, we recognize their limitations as a prediction tool, due to inadequate applications and overly simplified test conditions. We provide a critical review of in vitro and in vivo techniques currently used for evaluation of nanoparticles and introduce emerging techniques and models that may be used complementarily.