Portal de Periódicos da CAPES

Artigo Acesso aberto Produção Nacional Revisado por pares

BIBTEX RIS

Immunization of Saimiri sciureus Monkeys with Plasmodium falciparum Merozoite Surface Protein‐3 and Glutamate‐Rich Protein Suggests that Protection is Related to Antibody Levels

2004; Wiley; Volume: 59; Issue: 4 Linguagem: Inglês

10.1111/j.0300-9475.2004.01409.x

1365-3083

Leonardo J. M. Carvalho, Salma Gomes de Oliveira, Michael Theisen, Fábio Aguiar-Alves, Márcia Cristina Ribeiro Andrade, Graziela Maria Zaniní, Maria CO Brígido, Claude Oeuvray, Marinete Marins Póvoa, José Augusto Pereira Carneiro Muniz, Pierre Druilhe, Cláudio Tadeu Daniel‐Ribeiro,

Aquaculture disease management and microbiota

Abstract The immunogenicity and protective efficacy of various antigen‐adjuvant formulations derived either from the merozoite‐surface protein‐3 (MSP‐3) or the glutamate‐rich protein (GLURP) of Plasmodium falciparum were evaluated in Saimiri sciureus monkeys. These proteins were selected for immunogenicity studies based primarily on their capacity of inducing an antibody‐dependent cellular inhibition effect on parasite growth. Some of the S. sciureus monkeys immunized with MSP‐3 212−380 ‐AS02 or GLURP 27−500 ‐alum were able to fully or partially control parasitaemia upon an experimental P. falciparum [Falciparum Uganda Palo Alto (FUP‐SP) strain] blood‐stage infection, and this protection was related to the prechallenge antibody titres induced. The data are indicative that MSP‐3 and GLURP can induce protective immunity against an experimental P. falciparum infection using adjuvants that are acceptable for human use and this should trigger further studies with those new antigens.